According to research morphine, as little as a single dose obstructs the brain’s ability to strengthen connections at inhibitory synapses, the research also holds a provocative new theory of addiction as a disease of learning and memory. The research as shown that morphine makes lasting changes in the brain by blocking a mechanism that’s believed to be the key to memory making. So these findings reinforce the notion that addiction is a form of pathological learning. Finally the scientist concluded that net effect of morphine and other opioids, combined with other brain changes caused by the drugs, could increase vulnerability to addiction. The brain may, in fact, be learning to crave drugs.

While performing experiments on rats the scientist found that long-term potentiation, or LTP is blocked in the brains of rats given as little as a single dose of morphine. The drug’s impact was powerful.
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